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Adverse reactions commonly encountered in subjects treated with WELLBUTRIN are agitation.dry mouth.insomnia.headache/migraine.nausea/vomiting.constipation.tremor.dizziness.excessive sweating.blurred vision.tachycardia.confusion.rash.hostility.cardiac arrhythmia.and auditory disturbance.
Bupropion produced a positive response (2 to 3 times control mutation rate) in 2 of 5 strains in the Ames bacterial mutagenicity assay. Bupropion produced an increase in chromosomal aberrations in 1 of 3 in vivo rat bone marrow cytogenetic studies.
Factors or bupron delivery altering metabolic capacity (e.g..liver disease.congestive heart failure [CHF].age.concomitant medications.etc.) or elimination may be expected to influence the degree and extent of accumulation of the active metabolites of bupropion. The elimination of the major metabolites of bupropion may be affected by reduced renal or hepatic function because they are moderately polar compounds and are likely to undergo further metabolism or conjugation bupron delivery the liver prior to urinary excretion.
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