Like all other drugs, glucotrol xl may also cause mild to severe side effects in some patients.
Information about Glucotrol.
Gastrointestinal disturbances are the most common reactions. Gastrointestinal complaints were reported with the following approximate incidence. nausea and diarrhea.one in seventy. constipation and gastralgia.one in one hundred. Glucotrol cost appear to be dose-related and may disappear on division or reduction of dosage. Cholestatic jaundice may occur rarely with sulfonylureas. GLUCOTROL should be discontinued if this occurs.
It has been shown that GLUCOTROL therapy was effective in controlling blood sugar without deleterious changes in the plasma lipoprotein profiles of patients treated for NIDDM. In a placebo-controlled.crossover study in normal volunteers.GLUCOTROL had no antidiuretic activity and.in fact.led to a slight increase in free water clearance.
The Chemical Abstracts name of glipizide is 1-cyclohexyl-3-[[p-[2-(5-methylpyrazinecarboxamido) ethyl]phenyl]sulfonyl]urea. The molecular formula is C 21 H 27 N 5 O 4 S. the molecular weight is 445.55. the structural formula is shown below.
Similar drugs have caused severe low blood sugar in newborn babies whose mothers used the medicine near the time of delivery.
The major 12-year study in Taiwan found that while diabetes increases the risk of Parkinson’s 2.2 fold.including metformin in the therapy negates that risk.
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other sulfonylureas include glipizide glucotrol , glimepiride amaryl , tolbutamide orinase , tolazamide, and chlorpropamide diabinese .