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Grapefruit and grapefruit juice may interact with diltiazem and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.
Diltiazem can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
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This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.
There is no evidence.currently.that diltiazam or atenolol have any effect in slowing the development of hypertrophic cardiomyopathy. So their use is justified primarily by the development of clinical signs which require therapy. If there are no clinical signs it is reasonable to consider stopping the medications and monitoring carefully for signs of problems by keeping close track of respiratory rate and heart rate to be sure that you catch the development of clinical disease early. Increases in heart rate and respiratory rate occur when the damage to the heart reaches a point where it can’t function properly. This is the time when the use of medication is known to be beneficial. This approach does require careful attention on your part.though. I think that some vets prefer to go ahead with medication early.hoping to protect patients whose owners may price for cardizem the signs of worsening of the disease.
In animal models.diltiazem interferes with the slow inward (depolarizing) current in excitable tissue. Diltiazem causes excitation-contraction uncoupling in various myocardial. Diltiazem produces relaxation of coronary vascular smooth muscle and dilation of both large and small coronary arteries at drug levels which cause little or no negative inotropic effect. The resultant increases in coronary blood flow (epicardial and subendocardial) occur in ischemic and nonischemic models and are accompanied by dose-dependent decreases in systemic blood pressure and decreases in peripheral resistance.
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the different release profile of cardizem cd compared with dilzem sr or la may cause slight changes in blood pressure control.