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Based on its physical and order ponstel capsules properties.PONSTEL is expected to order ponstel capsules excreted in human breast milk (see PRECAUTIONS. Nursing Mothers ).
Taking mefenamic acid during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Clinical trials of several COX-2 selective and nonselective NSAIDs of up to three years duration have shown an increased risk of serious cardiovascular (CV) thrombotic events.including myocardial infarction (MI) and stroke.which can be fatal. Based on available data.it is unclear that the risk for CV thrombotic events is similar for all NSAIDs. The relative increase in serious CV thrombotic events over baseline conferred by NSAID use appears to be similar in those with and without known CV disease or risk factors for CV disease. However.patients with known CV disease or risk factors had a higher absolute incidence of excess serious CV thrombotic events.due to their increased baseline rate. Some observational studies found that this increased risk of serious CV thrombotic events began as early as the first weeks of treatment. The increase in CV thrombotic risk has been observed most consistently at higher doses.
Mefenamic acid pharmacokinetics have not been studied in patients with hepatic dysfunction. As hepatic metabolism is a significant pathway of mefenamic acid elimination.patients with acute and chronic hepatic disease may require reduced doses of PONSTEL compared to patients with normal order ponstel capsules function (see WARNINGS. Hepatotoxicity).
NSAIDs can also increase your risk of serious effects on the stomach or intestines.including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.
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