Depakote kadang-kadang digunakan bersama dengan obat kejang lainnya.

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Depakote contains the active ingredient divalproex sodium. This is a combination of sodium valproate and valproic acid.

The estimates cited apply primarily depakote prices patients who are not taking drugs that affect hepatic metabolizing enzyme systems. For example.patients taking enzyme-inducing antiepileptic drugs (carbamazepine.phenytoin.and phenobarbital) will clear valproate more rapidly. Because of these changes in valproate clearance.monitoring of antiepileptic concentrations should be intensified whenever concomitant antiepileptics are introduced or withdrawn.

In a patient who has epilepsy.quitting abruptly can cause seizures that will not stop (status epilepticus).

nausea.vomiting.mild stomach pain.diarrhea. headache.mild dizziness.weakness.tremors. problems with balance or walking. blurred vision.double vision. or changes in appetite.weight gain.

If you miss a dose.take it as soon as you remember. If it is near the time of the next dose.skip themissed dose and resume your usual dosing schedule. Do not double the dose to catch up.

The safety and effectiveness of Depakote for long-term use in mania.i.e..more than 3 weeks.has not been demonstrated in controlled clinical trials. providers who elect to use Depakote for extended periods should continually reevaluate the long-term usefulness of the drug for the individual patient.

Do not stop taking Depakote without first talking to your healthcare provider. Stopping Depakote suddenly can cause serious problems.

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in one, multi-clinic, placebo controlled study employing an add-on design adjunctive therapy , 144 patients who continued to suffer eight or more cps per 8 weeks during an 8 week period of monotherapy with doses of either carbamazepine or phenytoin sufficient to assure plasma concentrations within the therapeutic range were randomized to receive, in addition to their original antiepilepsy drug aed , either depakote or placebo.