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Once they have entered the cell by diffusion.the antimicrobial toxicity of the nitroimidazoles is dependent on reduction of the nitro moiety to the nitro anion radical and other highly active compounds.including nitroso and hydroxylamine derivatives. These reduction products are damaging to macromolecules.and have been shown to cause DNA degradation and strand breakage. The nitroimidazoles are selectively buy tinidazole online no prescription for micro-organisms in which the redox potential of components of the electron transport chain are sufficiently negative to reduce the nitro group of metronidazole (see also Chapter 137 ). Aerobic bacteria are therefore intrinsically resistant to these antibiotics since they are unable to attain the low intracellular redox environment required for drug activation. In susceptible organisms.the ongoing reduction of metronidazole maintains a favorable transmembrane metronidazole concentration gradient.facilitating further diffusion into the cell. In general.micro-organisms develop resistance to the nitroimidazoles by reducing or abolishing the activity of elements of the electron transport reactions.with appropriate compensatory modifications of the normal fermentative pathway. Resistance to metronidazole in Bacteroides spp. has been shown to be associated with specific nitroimidazole ( nim ) resistance genes that encode a 5-nitroimidazole reductase.which prevents the formation of the free radicals responsible for bactericidal buy tinidazole online no prescription. There is evidence of the emergence of reduced susceptibility to metronidazole in some Clostridium difficile isolates with evidence for clonal spread.although the clinical relevance of such strains remains unclear.
Do not share this medication with another person.even if they have the same symptoms you have.
Take this medication by mouth as directed by your doctor.usually once daily. To prevent stomach upset.take this medication with food. The dosage is based on your medical condition and response to treatment. For children.the dosage is also based on weight.
Drug-diagnostic tests . Alanine aminotransferase.aspartate aminotransferase.hexokinase glucose.lactate dehydrogenase.triglycerides. interference with test results.
You may begin nursing again 3 days after your last dose or tinidazole. If you use buy tinidazole online no prescription breast pump during treatment.throw out any milk you collect while taking tinidazole. Do not feed it to your baby.
Tinidazole can pass into breast milk and may harm a nursing baby. Do not breast-feed while you are taking tinidazole and for at least 3 days after your last dose.
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